Source: UT Southwestern University Summary: Researchers at have identified blood-based biomarkers that may help identify those patients at greatest risk of developing autoimmune side effects from the treatment.   More Information: Shaheen Khan et al, “Immune dysregulation in cancer patients developing immune-related adverse events”, British Journal of Cancer (2018). DOI: 10.1038/s41416-018-0155-1 Read More →

Cancer cells

Source: Queen Mary, University of London Summary: There is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be extended in people with triple-negative breast cancer. More Information: Peter Schmid et al, “Atezolizumab and Nab-Paclitaxel in Advanced Triple-NegativeRead More →

Use of immune system to treat cancer

Source: Johns Hopkins University School of Medicine Summary: Researchers discovered inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness of immunotherapy treatments. In order to investigate the role of the Yes-associated protein, or YAP, in T-cells in the cancer setting, scientists used mice genetically engineered to lack YAP in severalRead More →

Immune cells

Source: University of California – San Diego Summary: In a new study, researchers report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem cells (iPSCs) also displayed heightened activity against a mouse model of ovarian cancer. CAR-T cell-based immunotherapies have garnered considerable attention and investment in recent years.Read More →

Drug delivery system

Source: University of Michigan Summary: Researchers designed new delivery system, a drug hidden in a nanodisc to increase the number of patients who can be treated successfully with cancer immunotherapy drugs. To determine if cells are harmful to the body and need to be attacked, the immune system uses certain molecules called checkpoints. But some cancerRead More →

Gel with immune stimulating drug

Source: Dana-Farber Cancer Institute Summary: A new study by the researchers suggest, it may be possible to prevent tumors from recurring and to eradicate metastatic growths by implanting a gel containing immunotherapy during surgical removal of a tumor. Surgery is the main treatment option for patients with most solid tumors, butRead More →

Remote-controlled mechanogenetics system

Source: University of California – San Diego Summary: A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells. CAR-T therapy (Chimeric Antigen Receptor T-cell therapy) is becoming a paradigm-shifting therapeutic approach forRead More →

Chimeric Antigen Receptor T-Cells therapy

Source: University of California, Los Angeles Summary: Researchers through gene therapy, engineered blood-forming stem cells to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells. Antiviral drugs can suppress the amount of HIV (Human Immunodeficiency Virus) in the body to almost undetectable levels, but only anRead More →

Response of an immune system to the immune therapy drugs depends on individual’s genetic make up.

Source: Columbia University Medical Center Summary: Researchers have found that the response of an immune system to the immune therapy drugs depends on individual’s genetic makeup. When DNA inside the cells is mutated, leads to cancer cells which are recognized by the immune system as ‘foreign’. But cancer cells have foundRead More →

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