Genetic disease

Source: McGill University Health Centre Summary: An international team’s work has shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune response. Following the 2018 Nobel Prize for Medicine, global attention is now more than ever turned toward the promise of immunotherapyRead More →

Salmonella

Source: McMaster University Summary: Comparing two strains of Salmonella – one that causes disease in humans and the other in reptiles, researchers discovered a covert way that the human-affecting bacteria essentially tricks the immune system into not attacking. The immune system is very efficient at what it does, but if bacteria evolve ways to getRead More →

Cellular senescence

Source: University of Minnesota Summary: Researchers have shown that treatment of aged mice with the natural product Fisetin, found in many fruits and vegetables, also has significant positive effects on health and lifespan. As people age, they accumulate damaged cells. When the cells get to a certain level of damage theyRead More →

DNA damage

Source: Lancaster University Summary: Researchers have now discovered how skin cells alert the immune system when their DNA is damaged in the absence of infection. They found that DNA damage can lead to an immune response similar to that observed during viral infection. Our immune system is working every day to protect us from bacteria,Read More →

Lymphocyte type

Source: Duke University Medical Center Summary: Researchers have tracked the missing T-cells in glioblastoma patients. The findings open a new area of exploration for adjunct cancer drugs that could free trapped T-cells from the bone marrow and improve existing immunotherapies. Glioblastoma brain tumors can have an unusual effect on the body’s immune system,Read More →

Diabetes

Source: University of Alabama at Birmingham Summary: Researchers have discovered a safe and effective novel therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes. Type 1 diabetes occurs as the result of one’s immune system attacking the beta cells in the pancreas that produce insulin toRead More →

CD4+ T cells

Source: Monash University Summary: Researchers have discovered a unique set of “super” receptors on immune cells capable of killing HIV across genetically diverse populations, making them a potential candidate for immunotherapy treatments. While treatments for HIV mean that the disease is no longer largely fatal, the world still lacks a true therapy thatRead More →

Microgels

Source: Georgia Institute of Technology Summary: Researchers have opened a potentially new pathway for treating type 1 diabetes by instructing key immune system cells to accept transplanted insulin-producing islets. In the United States, some 1.25 million persons have type1 diabetes, which is different from the more common type 2 diabetes. TypeRead More →

Respiratory Virus

Source: Cardiff University Summary: Researchers has successfully ‘trained’ a respiratory virus to recognize ovarian cancer and completely destroy it without infecting other cells. In cancer treatment, up until now, reprogrammed viruses have not been able to selectively recognize only the cancer cells and would also infect healthy cells, resulting in unwanted side effects. Researchers fromRead More →

Tumor supressor genes get activated

Source: University of Michigan Summary: Researchers have found a connection between the cancer cell ‘swallowing’ certain molecules and its ability to activate tumor suppressor genes. Many cancers develop because of cell signaling problems. Signals must get from outside the cell into its nucleus to produce proteins. If the signal is altered,Read More →

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