MicroRNA

Source: Baylor College of Medicine Summary: Disturbing the normal function of microRNAs can lead to altered expression of their target genes, and this has been associated with a wide variety of human diseases, such as cancer, cardiovascular and developmental diseases.   More Information: Ninad Oak et al, “Framework for microRNA variantRead More →

Cytokines

Source: UT Southwestern University Summary: Researchers at have identified blood-based biomarkers that may help identify those patients at greatest risk of developing autoimmune side effects from the treatment.   More Information: Shaheen Khan et al, “Immune dysregulation in cancer patients developing immune-related adverse events”, British Journal of Cancer (2018). DOI: 10.1038/s41416-018-0155-1 Read More →

Lymphocyte type

Source: Duke University Medical Center Summary: Researchers have tracked the missing T-cells in glioblastoma patients. The findings open a new area of exploration for adjunct cancer drugs that could free trapped T-cells from the bone marrow and improve existing immunotherapies. Glioblastoma brain tumors can have an unusual effect on the body’s immune system,Read More →

Use of immune system to treat cancer

Source: Johns Hopkins University School of Medicine Summary: Researchers discovered inhibiting a previously known protein could reduce tumor burdens and enhance the effectiveness of immunotherapy treatments. In order to investigate the role of the Yes-associated protein, or YAP, in T-cells in the cancer setting, scientists used mice genetically engineered to lack YAP in severalRead More →

Peutz-Jeghers Syndrome

Source: McGill University Summary: The immune system can be an important ally in the fight against cancer. A study from suggests that the reverse may also be true.   More Information: “LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis” Science (2018).science.sciencemag.org/cgi/doi … 1126/science.aan3975Read More →

Melanocortin 4 receptor

Source: Linköping University Summary: According to a new study, mice that lack a certain receptor in the brain are attracted to situations associated with discomfort, such as inflammation and nausea. The brains of both humans and other animals have circuits that connect powerful impressions from the senses to positive or negative feelings – aRead More →

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