Source: Queen Mary, University of London Summary: There is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be extended in people with triple-negative breast cancer. More Information: Peter Schmid et al, “Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative
Source: Hokkaido University Summary: Researchers identified a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy. More Information: Yasuhito Onodera et al, “Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe, Nature Communications (2018). DOI: 10.1038/s41467-018-05087-7
Source: McMaster University Summary: Researchers have provided evidence of new cancerous cells they have termed cancer regenerating cells, which are responsible for the return of acute myeloid leukemia after remission. Current therapy is effective at inducing remission in adult patients with acute myeloid leukemia, but most patients later succumb after a relapse.
Source: National University of Singapore Summary: A research team has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma (HCC), or primary liver cancer. More Information: Bee Hui Liu et al, “Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide”, Proceedings of
Source: Garvan Institute for Medical Research Summary: According to new findings, a naturally occurring hormone could help make chemotherapy much more effective for many Australians with lung cancer. Despite advances in immunotherapy for lung cancer, most patients are still treated with chemotherapy based on a drug called cisplatin. However, less than a
Source: University of Illinois at Urbana-Champaign Summary: Researchers report that a class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer’s growth and spread. In 2017, the research team identified a new group of omega-3 fatty-acid metabolites called endocannabinoid epoxides, or EDP-EAs. They found that these molecules
Source: University of Notre Dame Summary: According to a recent study, Stiffer breast tissue creates an environment more prone to cancer by enabling the disease to interfere with the surrounding healthy cells. Fat cells, collagen fibers and epithelial cells make up the microenvironment of breast tissue. Cancer typically appears around the epithelial cells.
Source: Vanderbilt University Summary: For the first time researchers demonstrated that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital nutrient glutamine. Cancer cells exhibit unique metabolic demands that distinguish them biologically from otherwise healthy cells. The
Source: University of California – San Diego Summary: A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells. CAR-T therapy (Chimeric Antigen Receptor T-cell therapy) is becoming a paradigm-shifting therapeutic approach for
Source: Harvard Medical School Summary: A new study finds that breast cancer cells recycle ammonia and use it as a source of nitrogen to fuel tumor growth. During cell metabolic processes a waste byproduct, ammonia is released. The breast cancer cells use this ammonia as a source of nitrogen to cause