Drug delivery to treat cancer

Source: University of California Riverside Summary: Researchers have discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases. Tumor metastasis is a leading cause of patient morbidity and mortality, and no treatments are currently available that specifically targetRead More →

Cancer cells develop resistance against chemotherapy drugs

Source: Howard University Summary: Researchers reported that RECQ1, a breast cancer susceptibility gene potentially acts as a defense against chemotherapeutics and helps in promoting chemoresistance in cancer cells. Genomic instability is one of the key hallmarks of cancer development. Human DNA is constantly challenged by endogenous and exogenous sources that induce DNA damage.Read More →

Macrophages play a role early metastasis

Source: The Mount Sinai Hospital Summary: Researchers have discovered that normal immune cells play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed. Cancer cell dissemination during early stages of breast cancer proceeds through poorly understoodRead More →

Genetics of Breast Cancer

Source: University of Cambridge Summary: A major international collaboration of researchers worldwide identified new genetic variants which contribute to the risk of developing breast cancer. Researchers from all over the collaborated and identified 72 new genetic variants which contribute to the risk of developing breast cancer. Amongst these variants, 65 areRead More →

In the intensive search for new treatments against an aggressive form of breast cancer, triple-negative breast cancer, researchers at the University of Michigan Comprehensive Cancer Center created a powerful drug combo by combining a new protein inhibitor and a chemotherapy drug that results in cancer cell death. Triple-negative breast cancer (TNBC) is sub-typeRead More →

Researchers at Case Western Reserve University tested a new MRI (Magnetic Resonance Imaging) contrast agent which precisely locates breast cancer in its early stages and also differentiates between aggressive and slow-growing breast cancers. The contrast agent is a gadolinium-based agent which is more efficient and safer than the regular traditional agents. The dosageRead More →

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