Skipping Breakfast Disrupts ‘Clock Genes’ That Regulate Body Weight


Source: Tel Aviv University

Summary: Researchers in a new study pinpointed the effect of breakfast on clock gene expression which regulates the post-meal glucose and insulin responses in healthy and diabetic individuals.


Skipping breakfast is very much often linked to obesity, type 2 diabetes, hypertension and cardiovascular disease. The acute effect of meal time on body’s internal clock (circadian rhythm) has been less understood until now. The importance of body’s internal body clock was the subject of this year’s Nobel Prize for Medicine for the discovery of “molecular mechanisms controlling the circadian rhythm“. Researchers from Tel Aviv University in a new study pinpointed the effect of breakfast on clock gene expression which regulates the post-meal glucose and insulin responses in healthy and diabetic individuals. The research findings were published in the journal Diabetes Care.

The study recruited 18 healthy individuals and 18 obese individuals with diabetes who took part in the test day having breakfast and lunch, and on the test day having only lunch. Blood tests on both the days were conducted on the individuals and the researchers measured their postprandial clock gene expression, plasma glucose, insulin and intact glucagon-like peptide-1 (iGLP-1) and dipeptidyl peptidase IV (DPP-IV) plasma activity. The study finally showed that consumption of breakfast triggers proper cyclic clock gene expression in both healthy and diabetic individuals which led to improved glycaemic control and in individuals skipping breakfast led to weight gain.

Prof. Daniela Jakubowicz said, “Our study showed that breakfast consumption triggers the proper cyclic clock gene expression leading to improved glycaemic control”, “In both healthy individuals and in diabetics, breakfast consumption acutely improved the expression of specific clock genes linked to more efficient weight loss, and was associated with improved glucose and insulin levels after lunch.”


More Information: Daniela Jakubowic et al, “Influences of Breakfast on Clock Gene Expression and Postprandial Glycemia in Healthy Individuals and Individuals With Diabetes: A Randomized Clinical Trial”, Diabetes Care (2017). DOI: org/10.2337/dc16-2753


 

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