Mitochondria Come Together to Kill Cancer Cells

Source: Hokkaido University

Summary: Researchers identified a pathway that controls the movement of mitochondria, the powerhouses of all cells, could reduce cancer invasiveness and resistance to radiotherapy.

Powerhouse of a cell

Dispersed mitochondria (green, left) aggregated when Arf6 was disrupted (right) in a cancer cell, leading to excessive production of reactive oxygen species. Credit: Onodera Y., et al., Nature Communications

More Information:  Yasuhito Onodera et al, “Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe, Nature Communications (2018). DOI: 10.1038/s41467-018-05087-7 

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