‘Killer’ Kidney Cancers Identified by Studying Their Evolution


Source: The Francis Crick Institute

Summary: Researchers have discovered that kidney cancer follows distinct evolutionary paths, enabling them to detect whether a tumour will be aggressive and revealing that the first seeds of kidney cancer are sown as early as childhood.


 

Types of Kidney Cancer

Research shows that there are 7 types of kidney cancer which can be broadly categorized into 3 main groups based on their aggressiveness. Credit: Phospho Biomedical Animation

Sir Harpal Kumar, Cancer Research UK’s chief executive, said: “For years, we’ve grappled with why patients with seemingly very similar diagnoses have such vastly different outcomes – some dying very quickly and some surviving for decades after treatment. These ground-breaking studies help us unravel this conundrum.”


More Information: Samra Turajlic et al, “Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal”, Cell (2018). DOI: 10.1016/j.cell.2018.03.043


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