Ground-Breaking Approach Accelerates Drug Discovery Process


Source: Duke-NUS Medical School

Summary: An international collaboration between led to the discovery of a new anti-epileptic drug target and a whole new approach that promises to speed up the discovery of future drugs to treat debilitating diseases, such as epilepsy.


Causal Reasoning Analytical Framework for Target discovery'

Causal Reasoning Analytical Framework for Target discovery’ (CRAFT), an innovative method based on Systems Genetics and ‘big data,’ combines gene regulatory information with ‘causal reasoning’ to enable researchers to elucidate the mechanism of action of a disease, and computationally predict novel drug targets. Credit: Enrico Petretto


More Information: Prashant K. Srivastava et al, “A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target”, Nature Communications (2018). DOI: 10.1038/s41467-018-06008-4 


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