Gene PPM1D Gives Stem Cells a ‘Winning Boost’ After Chemotherapy

Source: Baylor College of Medicine

Summary: In this study, researchers combined clinical and laboratory studies to show that a gene called PPM1D, whose function in blood production was unknown, can confer blood cells exposed to the chemotherapy agent cisplatin a survival advantage that might favor the development of leukemia years later.


Gene PPM1D

Dr. Margaret A. Goodell, the corresponding author of this work. Credit: Baylor College of Medicine

More Information: Joanne I. Hsu et al, “PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy”, Cell Stem Cell (2018). DOI: 10.1016/j.stem.2018.10.004 

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