It is well known that enzyme, phosphatidic acid phosphatase plays a key role in regulating the quantity of fat in the human body. Therefore controlling it, is of high interest, in fighting against obesity. But researchers from Rutgers University-New Brunswick have found that entirely switching off this enzyme may increase the risk of cancer, inflammation and other diseases. The findings of this study are published online in the Journal of Biological Chemistry.
The researchers used baker’s yeast as a model organism as it has the same enzyme in it. Gil-Soo Han, the lead author of this study deleted a gene to eliminate the enzyme which leads to the accumulation of phosphatidic acid within the cells and making more membrane lipids than required, which further resulted in making too much membrane and the cells are permitted to grow with no control, a condition characteristic of cancer. People all over the world studied this enzyme because of its relation to obesity, inflammation, lipodystrophy, diabetes, cancer and other diseases.
Prof. George M. Carman said, “The goal of our lab is to understand how we can tweak and control this enzyme, the key take-home message is that things have to be balanced, to keep the balance between making storage fat and membrane lipid, you have to have balanced diet.”