Source: Cell Press
Summary: Researchers in a new study found that the circulatory blood flow impacts the position where circulating tumor cells ultimately arrest in the vasculature and exit into the body, where they can form a metastasis.
Lead author Jacky G. Goetz said, “We were able to merge the brain metastases map to a perfusion map of a control patient and found that it nicely reproduced exactly what we did in the zebrafish showing that metastases preferably develop in areas with low perfusion.”
More Information: Follain Gautier et al, “Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells”, Developmental Cell (2018). DOI: 10.1016/j.devcel.2018.02.015