Blood Flow is a Major Influence on Tumor Cell Metastasis


Source: Cell Press

Summary: Researchers in a new study found that the circulatory blood flow impacts the position where circulating tumor cells ultimately arrest in the vasculature and exit into the body, where they can form a metastasis.


Spread of cancer to other parts from its origin

This diagram shows the effect of blood flow on tumor metastasis. Credit: Jacky Goetz et al.

Lead author Jacky G. Goetz said, “We were able to merge the brain metastases map to a perfusion map of a control patient and found that it nicely reproduced exactly what we did in the zebrafish showing that metastases preferably develop in areas with low perfusion.”


More Information: Follain Gautier et al, “Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells”, Developmental Cell (2018). DOI: 10.1016/j.devcel.2018.02.015 


You may also like...

Leave a Reply

Your email address will not be published. Required fields are marked *